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Necrotizing enterocolitis: current perspectives

Authors Yajamanyam PK, Rasiah SV, Ewer AK

Received 18 October 2013

Accepted for publication 17 November 2013

Published 17 March 2014 Volume 2014:4 Pages 31—42

DOI https://doi.org/10.2147/RRN.S36576

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Phani Kiran Yajamanyam,1 Shree Vishna Rasiah,1 Andrew K Ewer1,2

1Neonatal Unit, Birmingham Women's Hospital NHS Foundation Trust, 2School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK

Abstract: Necrotizing enterocolitis is the most common gastrointestinal emergency in neonates, particularly in those born very preterm. It is a leading cause of morbidity and mortality, especially in extremely low birth weight infants. Despite extensive research, the pathophysiology of necrotizing enterocolitis remains unclear and therapeutic options are limited. Multiple risk factors have been reported, but most are associated with prematurity and its complications. This makes management very challenging in vulnerable preterm infants. In this review, we focus on the risk factors and some of the current research in this area, particularly studies aimed at early detection and potential preventive measures for this potentially lethal condition.

Keywords: necrotizing enterocolitis, preterm infants, prematurity, probiotics

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