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Whole-genome sequencing in bacteriology: state of the art

Authors Dark MJ

Received 9 August 2013

Accepted for publication 3 September 2013

Published 8 October 2013 Volume 2013:6 Pages 115—123


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Michael J Dark

Department of Infectious Diseases and Pathology and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA

Abstract: Over the last ten years, genome sequencing capabilities have expanded exponentially. There have been tremendous advances in sequencing technology, DNA sample preparation, genome assembly, and data analysis. This has led to advances in a number of facets of bacterial genomics, including metagenomics, clinical medicine, bacterial archaeology, and bacterial evolution. This review examines the strengths and weaknesses of techniques in bacterial genome sequencing, upcoming technologies, and assembly techniques, as well as highlighting recent studies that highlight new applications for bacterial genomics.

Keywords: bacterial genome sequencing assembly review

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