Back to Journals » Research and Reviews in Parkinsonism » Volume 2

Improvement in Central Pontine Myelinosis with IV immunoglobulin

Authors Ramos VFML, Fernandes Filho JA, Antony AR, Helvey JT, Bertoni J

Received 16 August 2012

Accepted for publication 16 August 2012

Published 2 April 2012 Volume 2012:2 Pages 24—26

DOI https://doi.org/10.2147/JPRLS.S37078



Vesper Fe Marie Llaneza Ramos,1 J Americo Fernandes Filho,1 Arun Raj Antony,1 Jason T. Helvey,2 John Bertoni1

1
Department of Neurological Sciences, University of Nebraska Medical Center; 2Department of Radiology, University of Nebraska Medical Center

Introduction: Central pontine myelinolysis (CPM) is a rare, serious demyelinating disease, associated with rapid correction of chronic hyponatremia, usually in the setting of alcoholism and electrolyte disturbance.1 2 Magnetic resonance imaging (MRI) is a decisive diagnostic tool for CPM.3 The pathogenesis is unknown and there is no established treatment. There have been case reports on the efficacy of intravenous immunoglobulin (IVIG).4 5 Postulated mech-anisms include reduction of myelinotoxic agents, development of antimyelin antibodies, and promotion of remyelination.4 We report a case of CPM associated with chronic alcoholism and hyponatremia, with significant clinical improvement and resolution of MRI changes after treatment with IVIG.

 

Creative Commons License © 2012 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.