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Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study

Authors Qian F, Zou W, Qin J, Li D

Received 25 August 2017

Accepted for publication 6 October 2017

Published 14 December 2017 Volume 2017:10 Pages 507—509

DOI https://doi.org/10.2147/IDR.S149992

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Joachim Wink

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Fuchu Qian,1 Weihua Zou,2 Jiqu Qin,1 Dongli Li1

1Huzhou Key Laboratory of Molecular Medicine, 2Department of Laboratory Medicine, Huzhou Central Hospital, Huzhou, China

China is an area with highly endemic hepatitis B virus (HBV) infection, with an estimated 93 million HBV carriers, resulting in approximately 330,000 deaths annually.1 The predominant HBV genotypes in China are genotype B and C. Currently,  nucleos(t)ide analogs are used for anti-HBV treatment. However, prolonged antiviral therapy may lead to drug resistance, which is associated with mutations in the reverse transcriptase region of the HBV genome. Several studies have shown that drug-resistant mutations existed in treatment-naïve patients with chronic hepatitis B (CHB). However, the prevalence rates of natural drug-resistant mutations varied in different reports.2,3 Furthermore, the prevalence and clinical profile of natural drug-resistant mutations in CHB patients are not quite clear. Thus, the purpose of this study was to investigate the prevalence and clinical feature of natural drug-resistant mutations among treatmentnaïve CHB patients in a tertiary hospital in Huzhou, eastern China.


Acknowledgment

This work was supported by grants from the Foundation Projects for Science and Technology of Huzhou City (No. 2014GY12, No. 2017GY30).

Disclosure

The authors report no conflicts of interest in this work.

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Qian F, Qin J, Li D, et al. Monitoring of genotypic resistance profile in chronic hepatitis B patients receiving nucleos(t)ide analogues in Huzhou, China. J Infect Dev Ctries. 2016;10:996–1002.

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Xu J, Wu B, Wang JH, et al. Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive Chinese patients with chronic hepatitis B. PLoS One. 2015;10:e0117429.

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