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Nanotubular surface modification of metallic implants via electrochemical anodization technique

Authors Wang LN, Jin M, Zheng Y, Guan Y, Lu X, Luo JL

Received 10 April 2014

Accepted for publication 12 May 2014

Published 17 September 2014 Volume 2014:9(1) Pages 4421—4435

DOI https://doi.org/10.2147/IJN.S65866

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Lu-Ning Wang,1 Ming Jin,1 Yudong Zheng,1 Yueping Guan,1 Xin Lu,1 Jing-Li Luo2

1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, People’s Republic of China; 2Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada

Abstract: Due to increased awareness and interest in the biomedical implant field as a result of an aging population, research in the field of implantable devices has grown rapidly in the last few decades. Among the biomedical implants, metallic implant materials have been widely used to replace disordered bony tissues in orthopedic and orthodontic surgeries. The clinical success of implants is closely related to their early osseointegration (ie, the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant), which relies heavily on the surface condition of the implant. Electrochemical techniques for modifying biomedical implants are relatively simple, cost-effective, and appropriate for implants with complex shapes. Recently, metal oxide nanotubular arrays via electrochemical anodization have become an attractive technique to build up on metallic implants to enhance the biocompatibility and bioactivity. This article will thoroughly review the relevance of electrochemical anodization techniques for the modification of metallic implant surfaces in nanoscale, and cover the electrochemical anodization techniques used in the development of the types of nanotubular/nanoporous modification achievable via electrochemical approaches, which hold tremendous potential for bio-implant applications. In vitro and in vivo studies using metallic oxide nanotubes are also presented, revealing the potential of nanotubes in biomedical applications. Finally, an outlook of future growth of research in metallic oxide nanotubular arrays is provided. This article will therefore provide researchers with an in-depth understanding of electrochemical anodization modification and provide guidance regarding the design and tuning of new materials to achieve a desired performance and reliable biocompatibility.

Keywords: nanotubular arrays, anodization, implant, bioactivity, in vitro, in vivo

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