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Nanotheranostics – a review of recent publications

Authors Wang LS, Chuang MC, Ho JA

Received 17 April 2012

Accepted for publication 14 May 2012

Published 23 August 2012 Volume 2012:7 Pages 4679—4695

DOI https://doi.org/10.2147/IJN.S33065

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Li-Sheng Wang, Min-Chieh Chuang, Ja-an Annie Ho

Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan

Abstract: Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented.

Keywords: theranostics, therapeutics, diagnostics, nanomaterial

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