Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy
Authors Li X, Jia X, Niu H
Received 28 January 2018
Accepted for publication 5 March 2018
Published 12 July 2018 Volume 2018:13 Pages 4107—4119
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alicia Fernandez-Fernandez
Peer reviewer comments 4
Editor who approved publication: Dr Linlin Sun
Xin Li,1 Xiaoqian Jia,2 Hu Niu2
1Department of Breast and Thyroid Surgery, Heze Municipal Hospital, Heze, Shandong, China; 2Department of General Surgery 2, The Fourth People’s Hospital of Jinan, Jinan, Shandong, China
Background: Multidrug resistance is responsible for the poor outcome in breast cancer therapy. Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P)H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-delivered DOX to overcome MDR in cancer cells.
Purpose: Herein, in our study, nanostructured lipid carrier (NLC) co-delivering β-lapachone (Lapa) and doxorubicin (DOX) was developed (LDNLC) with the aim to overcome the multidrug resistance (MDR) in breast cancer therapy.
Patients and methods: Lapa and DOX were loaded into NLC to prepare LDNLC using melted ultrasonic dispersion method.
Results: The well designed LDNLC was nanoscaled particles that exhibited preferable stability in physiological environment. In vitro cell experiments on MCF-7 ADR cells showed increased DOX retention as compared to DOX mono-delivery NLC (DNLC). In vivo anti-cancer assays on MCF-7 ADR tumor bearing mice model also revealed significantly enhanced efficacy of LDNLC than mono-delivery NLCs (DNLC and LNLC).
Conclusion: LDNLC might be a promising platform for effective breast cancer therapy.
Keywords: β-lapachone, doxorubicin, nanostructured lipid carriers, multidrug resistance, breast cancer
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