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Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

Authors Pang Z, Pan Z, Ma M, Xu Z, Mei S, Jiang Z, Yin F

Received 17 October 2020

Accepted for publication 23 December 2020

Published 29 January 2021 Volume 2021:16 Pages 725—740


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Ebrahim Mostafavi

Zhiying Pang,1,* Zhangyi Pan,1,* Min Ma,1 Zhiyan Xu,2 Shiqi Mei,2 Zengxin Jiang,3 Feng Yin1

1Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, People’s Republic of China; 2Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China; 3Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zengxin Jiang Tel +86 21-64041990
Feng Yin Tel +86 21-64041990

Purpose: As a dental material, polyetheretherketone (PEEK) is bioinert that does not induce cellular response and bone/gingival tissues regeneration. This study was to develop bioactive coating on PEEK and investigate the effects of coating on cellular response.
Materials and Methods: Tantalum pentoxide (TP) coating was fabricated on PEEK surface by vacuum evaporation and responses of rat bone marrow mesenchymal stem (RBMS) cells/human gingival epithelial (HGE) were studied.
Results: A dense coating (around 400 nm in thickness) of TP was closely combined with PEEK (PKTP). Moreover, the coating was non-crystalline TP, which contained many small humps (around 10 nm in size), exhibiting a nanostructured surface. In addition, the roughness, hydrophilicity, surface energy, and protein adsorption of PKTP were remarkably higher than that of PEEK. Furthermore, the responses (adhesion, proliferation, and osteogenic gene expression) of RBMS cells, and responses (adhesion and proliferation) of HGE cells to PKTP were remarkably improved in comparison with PEEK. It could be suggested that the nanostructured coating of TP on PEEK played crucial roles in inducing the responses of RBMS/HGE cells.
Conclusion: PKTP with elevated surface performances and outstanding cytocompatibility might have enormous potential for dental implant application.

Keywords: polyetheretherketone, tantalum pentoxide, nanostructured coating, cytocompatibility, dental implant applications

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