Back to Journals » International Journal of Nanomedicine » Volume 13

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Authors Ullah Khan S, Saleh TA, Wahab A, Khan MHU, Khan D, Ullah Khan W, Rahim A, Kamal S, Ullah Khan F, Fahad S

Received 3 October 2017

Accepted for publication 9 December 2017

Published 2 February 2018 Volume 2018:13 Pages 733—762


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster

Shahid Ullah Khan,1,2 Tawfik A Saleh,3 Abdul Wahab,4 Muhammad Hafeez Ullah Khan,1,2 Dilfaraz Khan,5 Wasim Ullah Khan,6 Abdur Rahim,7 Sajid Kamal,8 Farman Ullah Khan,9 Shah Fahad1,10

1College of Plant Sciences and Technology, 2National Key Laboratory of Crop Genetics Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China; 3Department of Chemistry, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia; 4Department of Pharmacy, Kohat University of Science and Technology, Kohat, 5Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan; 6School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 7Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore, Pakistan; 8School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; 9Department of Chemistry, University of Science and Technology, Bannu, 10Department of Agriculture, University of Swabi, Swabi, Pakistan

Abstract: Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.

Keywords: synthesis of AgNPs, theranostics, antimicrobial properties, biomedical applications of AgNPs

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]