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Nanoparticles in tissue engineering: applications, challenges and prospects

Authors Hasan A, Morshed M, Memic A, Hassan S, Webster TJ, Marei HE

Received 11 October 2017

Accepted for publication 26 March 2018

Published 24 September 2018 Volume 2018:13 Pages 5637—5655

DOI https://doi.org/10.2147/IJN.S153758

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Anwarul Hasan,1 Mahboob Morshed,2 Adnan Memic,3 Shabir Hassan,4,5 Thomas J Webster,6 Hany El-Sayed Marei7

1Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar; 2School of Life Sciences, Independent University, Bangladesh (IUB), Dhaka, Bangladesh; 3Center of Nanotechnology, King Abdulaziz University, Jeddah, Saudi Arabia; 4Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; 6Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 7Biomedical Research Center, Qatar University, Doha, Qatar

Abstract: Tissue engineering (TE) is an interdisciplinary field integrating engineering, material science and medical biology that aims to develop biological substitutes to repair, replace, retain, or enhance tissue and organ-level functions. Current TE methods face obstacles including a lack of appropriate biomaterials, ineffective cell growth and a lack of techniques for capturing appropriate physiological architectures as well as unstable and insufficient production of growth factors to stimulate cell communication and proper response. In addition, the inability to control cellular functions and their various properties (biological, mechanical, electrochemical and others) and issues of biomolecular detection and biosensors, all add to the current limitations in this field. Nanoparticles are at the forefront of nanotechnology and their distinctive size-dependent properties have shown promise in overcoming many of the obstacles faced by TE today. Despite tremendous progress in the use of nanoparticles over the last 2 decades, the full potential of the applications of nanoparticles in solving TE problems has yet to be realized. This review presents an overview of the diverse applications of various types of nanoparticles in TE applications and challenges that need to be overcome for nanotechnology to reach its full potential.

Keywords: nanoparticles, tissue engineering, antibacterial applications, mechanotransduction, gene delivery

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