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Nanomaterials in the application of tumor vaccines: advantages and disadvantages
Authors Li XD, Gao JY, Yang Y, Fang HY, Han YJ, Wang XM, Ge W
Received 20 December 2012
Accepted for publication 1 March 2013
Published 5 June 2013 Volume 2013:6 Pages 629—634
DOI https://doi.org/10.2147/OTT.S41902
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
XD Li,2,* JY Gao,1,* Y Yang,1,* HY Fang,1 YJ Han,1 XM Wang,1 W Ge1
1Department of Geriatrics, 2Department of Equipment, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
*These authors contributed equally to this work
Abstract: Tumor vaccines are a novel approach to the treatment of malignancy, and are attracting the attention of the medical profession. Nanomaterials have significant advantages in the preparation of a tumor vaccine, including their ability to penetrate and target cancer tissue and their antigenic properties. In this review, we focus on several nanomaterials, ie, carbon nanotubes, nanoemulsions, nanosized aluminum, and nanochitosan. Applications for these nanomaterials in nanovaccines and their biological characteristics, as well as their potential toxicity, are discussed.
Keywords: nanomaterials, tumor vaccine, carbon nanotubes, nanoemulsions, nanosized aluminum, nanochitosan
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