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Nanomaterials in the application of tumor vaccines: advantages and disadvantages

Authors Li XD, Gao JY, Yang Y, Fang HY, Han YJ, Wang XM, Ge W

Received 20 December 2012

Accepted for publication 1 March 2013

Published 5 June 2013 Volume 2013:6 Pages 629—634

DOI https://doi.org/10.2147/OTT.S41902

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

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XD Li,2,* JY Gao,1,* Y Yang,1,* HY Fang,1 YJ Han,1 XM Wang,1 W Ge1

1Department of Geriatrics, 2Department of Equipment, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China

*These authors contributed equally to this work

Abstract: Tumor vaccines are a novel approach to the treatment of malignancy, and are attracting the attention of the medical profession. Nanomaterials have significant advantages in the preparation of a tumor vaccine, including their ability to penetrate and target cancer tissue and their antigenic properties. In this review, we focus on several nanomaterials, ie, carbon nanotubes, nanoemulsions, nanosized aluminum, and nanochitosan. Applications for these nanomaterials in nanovaccines and their biological characteristics, as well as their potential toxicity, are discussed.

Keywords: nanomaterials, tumor vaccine, carbon nanotubes, nanoemulsions, nanosized aluminum, nanochitosan

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