Back to Journals » International Journal of Nanomedicine » Volume 13

Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy

Authors Qi W, Yan J, Sun H, Wang H

Received 5 April 2018

Accepted for publication 3 July 2018

Published 9 October 2018 Volume 2018:13 Pages 6235—6247


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Dr Linlin Sun

Wei Qi, Jing Yan, Haifeng Sun, Hua Wang

Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China

Introduction: Novel nanomedical systems are being developed as multiple therapeutic modalities because the combinational therapies for cancer on a single platform can have larger chance to address tumor heterogeneity and drug resistance than any mono-therapeutic modality.
Methods: In this study, photothermal therapy (PTT) and chemotherapy (CT) were combined to treat squamous cell carcinoma by using a novel type of noninvasive plaster composed of carboxylated-reduced graphene oxide (rGO–COOH), gold nanorods (Au NRs), and doxorubicin (DOX). Firstly, DOX was loaded onto rGO–COOH to form DOX_rGO–COOH. Then, the obtained DOX_rGO–COOH and Au NRs were co-assembled to obtain nanocomposite multilayer. rGO–COOH and Au NRs were combined together to obtain high light-to-heat conversion efficiency. Using them as photothermal agents for PTT and using DOX in rGO–COOH as an anticancer drug for CT, their synergistic combination therapy could be applicable practically.
Results: As a result, DOX_rGO–COOH/Au NRs showed higher photothermal effects than that showed by rGO–COOH or Au NRs alone. It also showed higher therapeutic effects than DOX_rGO–COOH (for CT) or Au nr (for PTT) alone. Moreover, the system can repeatedly produce heat and simultaneously stimulate the release of the encapsulated anticancer drug into the tumor upon being irradiated by near-infrared laser. In vivo experiments demonstrated that the squamous cell carcinoma-bearing mice treated with DOX_rGO–COOH/Au NRs were healthy for more than 60 days without tumor recurrence.
Conclusion: The as-developed DOX_rGO–COOH/Au NRs plaster could be an effective, convenient, and noninvasive treatment option for treating superficial tumors.

Keywords: nanocomposite plaster, carboxylated-reduced graphene oxide, doxorubicin, Au nanorods, superficial tumor

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]