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Nab-paclitaxel and trastuzumab combination: a promising approach for neoadjuvant treatment in HER2-positive breast cancer

Authors Ricciardi GRR, Franchina T, Russo A, Schifano S, Ferraro G, Adamo V

Received 7 March 2016

Accepted for publication 7 May 2016

Published 21 July 2016 Volume 2016:9 Pages 4351—4355

DOI https://doi.org/10.2147/OTT.S107930

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 3

Editor who approved publication: Professor Min Li


Giuseppina Rosaria Rita Ricciardi, Tindara Franchina, Alessandro Russo, Silvia Schifano, Giuseppa Ferraro, Vincenzo Adamo

Human Pathology University Department & Medical Oncology Unit AO Papardo, Messina, Italy


Abstract: Neoadjuvant therapy is a well-established approach for the treatment of locally advanced or inflammatory breast cancer (BC) and has been increasingly used in recent years not only as a management strategy but also as a research tool. Recently, nanoparticle albumin-bound paclitaxel (nab-paclitaxel)/trastuzumab combinations have been associated with promising activity in different clinical settings. In the present case, we report a complete pathological response after neoadjuvant treatment with the trastuzumab/nab-paclitaxel combination in a locally advanced human epidermal growth factor receptor 2 (HER2)-positive BC patient, with a good toxicity profile. This combination may represent a valid therapeutic option in the neoadjuvant therapy for HER2-positive locally advanced BC.

Keywords: breast cancer, HER2-positive, nab-paclitaxel, trastuzumab, neoadjuvant therapy, pathologic complete response

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