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Myocardial T1 mapping: where are we now and where are we going?

Authors Abdel-Gadir A, Treibel T, Moon J

Received 23 June 2014

Accepted for publication 30 July 2014

Published 26 November 2014 Volume 2014:5 Pages 339—347


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Richard Kones

Amna Abdel-Gadir,1,2 Thomas A Treibel,1,2 James C Moon1,2

1The Heart Hospital Imaging Centre, University College London Hospitals, London, UK; 2Institute of Cardiovascular Science, University College London, London, UK

Abstract: Cardiovascular magnetic resonance offers noninvasive myocardial tissue characterization as a key unique strength over other imaging techniques. In particular T1, a tissue property that alters with disease, has gained prominence as a diagnostic tool. Prior to the administration of contrast, the native T1 changes with a number of processes such as fibrosis, edema, and infiltration. If a post-contrast scan is also acquired, the post-contrast T1 and extracellular volume fraction can be measured. Detecting and quantifying early and established myocardial pathological processes permits better diagnosis, prognostication, and tracking of therapy.

Keywords: extracellular volume fraction, diffuse fibrosis, interstitium, cardiac remodeling, myocardial intracellular volume

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