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Mutations in hepatitis B virus small S genes predict postoperative survival in hepatocellular carcinoma

Authors Peng L, Yang G, Wu C, Wang WS, Wu J, Guo Z

Received 7 September 2016

Accepted for publication 9 November 2016

Published 2 December 2016 Volume 2016:9 Pages 7367—7372


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Carlos E Vigil

Li Peng,1 Guang Yang,2 Chensi Wu,3 Wenshuai Wang,1 Jianhua Wu,4 Zhanjun Guo3

1Department of Hepatobiliary Surgery, 2Department of Radiology, 3Department of Gastroenterology and Hepatology, 4Animal Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China

Abstract: Hepatitis B virus (HBV) DNA is prone to mutations due to proofreading deficiencies of HBV polymerase. We have previously identified hepatocellular carcinoma (HCC) survival–associated HBV mutations in the X, precore, and core regions. In the present study, we extended our research to assess HCC survival–associated HBV mutations in the small S gene of HBV genome in 115 HCC patients including 60 patients with HBV B genotype, 52 patients with HBV C genotype, and 3 patients with other genotypes. The overfrequencies of mutations at nucleotides 529 and 735 are 8.5% and 91.5%, respectively, but the distribution frequencies of these mutations are not different between HBV genotypes B and C. Mutational sites 529 (relative risk: 3.611, 95% confidence interval [CI]: 1.414–9.221, P=0.007) and 735 (relative risk: 1.905, 95% CI: 1.101–3.297, P=0.021) were identified as statistically significant independent predictors for HCC survival by multivariate survival analysis using a Cox proportional hazards model. Moreover, the mutated 529A and 735T were associated with both short survival time and high HBV DNA load score in HCC patients. The analysis of DNA mutations in the HBV S gene may help identify HCC subgroups with poor prognosis and may provide reference for therapeutic decisions.

Keywords: HCC, HBV, survival, S gene, mutations

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