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Multiparametric autoimmune diagnostics: recent advances

Authors Damoiseaux J

Received 3 September 2015

Accepted for publication 23 February 2016

Published 27 April 2016 Volume 2016:8 Pages 15—25

DOI https://doi.org/10.2147/PLMI.S56781

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Xuehui Li

Peer reviewer comments 3

Editor who approved publication: Dr Paul Zhang


Jan Damoiseaux

Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands

Abstract: Autoimmune diagnostics in a routine clinical laboratory is constantly challenged by the discovery of new autoantibodies and technical innovations in the immunoassays applied. These challenges are, in particular, combined in the multiparametric immunoassays. Appropriate positioning of multiparametric immunoassays within the laboratory requires integrated knowledge of the clinical performance of the test system for each individual antigen, the conditions prescribed in disease criteria and/or guidelines, and the demands of the clinicians. This review provides a summary of the multiparametric immunoassays available, as well as the applications and restrictions in routine clinical practice.

Keywords: autoantibodies, line immunoassay, dot immunoassay, addressable laser bead immunoassay, indirect immunofluorescence

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