Back to Journals » International Journal of Nanomedicine » Volume 9 » Issue 1

Multifunctional materials for bone cancer treatment

Authors Marques C, Ferreira JMF, Andronescu E, Ficai D, Sonmez M, Ficai A

Received 14 October 2013

Accepted for publication 24 November 2013

Published 28 May 2014 Volume 2014:9(1) Pages 2713—2725

DOI https://doi.org/10.2147/IJN.S55943

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Catarina Marques,1 José MF Ferreira,1 Ecaterina Andronescu,2 Denisa Ficai,2 Maria Sonmez,3 Anton Ficai2

1Department of Materials and Ceramics Engineering, Centre for Research in Ceramics and Composite Materials, University of Aveiro, Aveiro, Portugal; 2Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania; 3National Research and Development Institute for Textiles and Leather, Bucharest, Romania

Abstract: The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen–hydroxyapatite composites used for skin and bone cancer treatments. The multifunctionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

Keywords: bone graft, cancer, collagen, magnetite, cytostatics, silver

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Antitumoral materials with regenerative function obtained using a layer-by-layer technique

Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C

Drug Design, Development and Therapy 2015, 9:1269-1279

Published Date: 2 March 2015

Readers of this article also read:

Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera

Marslin G, Selvakesavan RK, Franklin G, Sarmento B, Dias ACP

International Journal of Nanomedicine 2015, 10:5955-5963

Published Date: 22 September 2015

Development of a liposome-based formulation for vitamin K1 nebulization on the skin

Campani V, Marchese D, Pitaro MT, Pitaro M, Grieco P, De Rosa G

International Journal of Nanomedicine 2014, 9:1823-1832

Published Date: 10 April 2014

Pathogenesis of hyperinflation in chronic obstructive pulmonary disease

Gagnon P, Guenette JA, Langer D, Laviolette L, Mainguy V, Maltais F, Ribeiro F, Saey D

International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:187-201

Published Date: 15 February 2014

P-wave indices in patients with pulmonary emphysema: do P-terminal force and interatrial block have confounding effects?

Chhabra L, Chaubey VK, Kothagundla C, Bajaj R, Kaul S, Spodick DH

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:245-250

Published Date: 14 May 2013

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010