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Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release

Authors Manaia EB, Kaminski RCK, Oliveira AG, Corrêa MA, Chiavacci LA

Received 30 July 2014

Accepted for publication 11 October 2014

Published 22 January 2015 Volume 2015:10(1) Pages 811—819

DOI https://doi.org/10.2147/IJN.S71980

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster

Eloísa Berbel Manaia,1 Renata Cristina Kiatkoski Kaminski,2 Anselmo Gomes de Oliveira,1 Marcos Antonio Corrêa,1 Leila Aparecida Chiavacci1

1Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, 2Physical-Chemistry Department, Chemistry Institute, São Paulo State University – UNESP, Araraquara, Brazil

Abstract: Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO2) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO2 nanoparticles can act as a transparent inorganic sunscreen.

Keywords: titanium dioxide, sol-gel, drug delivery, sunscreen

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