Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Authors Vellayappan MV, Balaji A, Subramanian AP, John AA, Jaganathan SK, Murugesan S, Supriyanto E, Yusof M

Received 31 December 2014

Accepted for publication 3 February 2015

Published 7 April 2015 Volume 2015:10(1) Pages 2785—2803

DOI https://doi.org/10.2147/IJN.S80121

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Thomas J Webster

Muthu Vignesh Vellayappan,1 Arunpandian Balaji,1 Aruna Priyadarshini Subramanian,1 Agnes Aruna John,1 Saravana Kumar Jaganathan,1 Selvakumar Murugesan,2 Eko Supriyanto,1 Mustafa Yusof1

1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2Rubber Technology Center, Indian Institute of Technology, Kharagpur, India

Abstract: Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.

Keywords: nanocomposites, vascular grafts, stents, hemocompatibility, nanoparticles, cardiovascular biomaterials

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Balaji A, Jaganathan SK, Supriyanto E, Muhamad II, Khudzari AZM

International Journal of Nanomedicine 2015, 10:5909-5923

Published Date: 18 September 2015

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

John AA, Subramanian AP, Vellayappan MV, Balaji A, Mohandas H, Jaganathan SK

International Journal of Nanomedicine 2015, 10:4267-4277

Published Date: 2 July 2015

Readers of this article also read:

Spotlight on tavaborole for the treatment of onychomycosis

Jinna S, Finch J

Drug Design, Development and Therapy 2015, 9:6185-6190

Published Date: 20 November 2015

Evaluating preferences for profiles of GLP-1 receptor agonists among injection-naïve type 2 diabetes patients in the UK

Gelhorn HL, Poon JL, Davies EW, Paczkowski R, Curtis SE, Boye KS

Patient Preference and Adherence 2015, 9:1611-1622

Published Date: 9 November 2015

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery

Matsuura K, Mori T, Miyamoto T, Suto C, Saeki Y, Tanaka S, Kawamura H, Ohkubo S, Tanito M, Inoue Y

Clinical Ophthalmology 2014, 8:2013-2018

Published Date: 29 September 2014

Fluorescence resonance energy transfer-based real-time polymerase chain reaction method without DNA extraction for the genotyping of F5, F2, F12, MTHFR, and HFE

Martinez-Serra J, Robles J, Nicolàs A, Gutierrez A, Ros T, Amat JC, Alemany R, Vögler O, Abelló A, Noguera A, Besalduch J

Journal of Blood Medicine 2014, 5:99-106

Published Date: 25 June 2014

Non-adherence to topical treatments for actinic keratosis

Shergill B, Zokaie S, Carr AJ

Patient Preference and Adherence 2014, 8:35-41

Published Date: 17 December 2013