Back to Journals » Infection and Drug Resistance » Volume 12

Multidrug-Resistant Tuberculosis In A Referral Center In Rome: 2011– 2016

Authors Cannas A, Butera O, Gualano G, Parracino MP, Venditti C, Mazzarelli A, Palmieri F, Girardi E, Di Caro A

Received 8 June 2019

Accepted for publication 12 August 2019

Published 18 October 2019 Volume 2019:12 Pages 3275—3281

DOI https://doi.org/10.2147/IDR.S218744

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


A Cannas,1 O Butera,1 G Gualano,2 MP Parracino,3 C Venditti,1 A Mazzarelli,1 F Palmieri,2 E Girardi,3,* A Di Caro1,*

1Microbiology and Bio-Repository Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy; 2Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy; 3Clinical Epidemiology Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy

*These authors contributed equally to this work

Correspondence: A Cannas
National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Via Portuense 292, Rome 00149, Italy
Tel +39 06 5517 0905
Email angela.cannas@inmi.it

Purpose: Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in low incidence countries in Europe. The aim of this study was to attempt to have a better insight into the trends of MDR-TB in the metropolitan area of Rome, within the Italian and the foreign-born population, based on microbiological and demographic data.
Patients and methods: We performed a prospective study, collecting microbiological data based on phenotypic drug-resistant testing (DST) of TB strains consecutively isolated in a referral hospital in Rome, the capital city of a low TB incidence country, over a 6-year period, and correlated them to the geographical origin of patients. This study was carried out in a referral hospital for patients with drug-resistant TB from the whole region.
Results: Drug-resistance data from 926 patients with a microbiological diagnosis of TB from 2011 to 2016 show a 5.5% rate of MDR-TB, mostly occurring in patients born in a single East European country, that has a high incidence of MDR-TB. The strains isolated from these patients frequently carry additional resistances, leading to an increased risk of developing extensively drug-resistant (XDR) TB.
Conclusion: In the great metropolitan area of Rome, MDR-TB more frequently occurs in patients who were born in a single country from Eastern Europe known to have high rates of MDR-TB and long-time residents in Italy. Recent immigrants from non-European countries do not appear to contribute to the rates of MDR-TB reported in this article. This knowledge of local TB trends could help improve the measures of surveillance and prevention of disease.

Keywords: tuberculosis, drug-susceptibility testing, MDR-TB, XDR-TB

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]