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Multidrug-Resistant Acinetobacter baumannii – The Modern Menace: A Retrospective Study in a Tertiary Hospital in Mangalore

Authors Ashuthosh KC, Hegde A, Rao P, Manipura R

Received 11 February 2020

Accepted for publication 14 June 2020

Published 7 July 2020 Volume 2020:13 Pages 2181—2187

DOI https://doi.org/10.2147/IDR.S249123

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eric Nulens


K C Ashuthosh, Ashwini Hegde, Pooja Rao, Radhakrishna Manipura

Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal 576104, India

Correspondence: Radhakrishna Manipura
Department of Microbiology, Kasturba Medical College, Mangalore, Karnataka, India
(A Constituent Unit of Manipal Academy of Higher Education, Manipal) Tel +919448163835
Fax +918242428183
Email manipuraradhakrishna@yahoo.com

Background: Multidrug resistance in Acinetobacter baumannii is constantly on the rise. There has also been an increase in the morbidity and mortality of patients with infection by the same pathogen.
Aim: This study aimed to assess the patterns of antibiotic resistance exhibited by various clinical isolates of Acinetobacter baumannii, examine the risk factors associated, and investigate the prevalence of co-infecting pathogens and the clinical outcomes of the patients.
Study Design: Retrospective cross-sectional study.
Patients and Methods: Reports of 100 isolates of Acinetobacter baumannii obtained from patients admitted in two tertiary hospitals were used for the study. Identification and determination of antibiotic resistance patterns were done using Vitek2. The presence of probable risk factors was noted. The pattern of clinical outcomes of the patients and the prevalence of co-infecting pathogens were analyzed. Data analysis was done using descriptive statistics.
Results: More than 50% of isolates showed resistance independently to imipenem and meropenem. Higher rates of susceptibility were observed with tigecycline (55%). Isolates obtained from patients in the intensive care unit (ICU) showed resistance to a more number of antibiotics than those in the wards and operation theatre. Seventeen percent of the isolates were associated with a co-infecting pathogen such as Pseudomonas, Enterococcus, Klebsiella, 87% of the patients were discharged, 12% expired, and 1% were shifted. A positive correlation was found between the duration of hospital stay and number of antibiotics to which the isolate was resistant.
Conclusion: Multidrug resistance in Acinetobacter baumannii continues to be a menace. In this study, a large number of isolates exhibited resistance to carbapenems such as imipenem, meropenem, and ertapenem, thereby signifying the need for further research and the use of other antibiotics such as tigecycline, to which higher susceptibility was observed.

Keywords: multidrug resistance, clinical outcomes, nosocomial infection

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