Back to Journals » Infection and Drug Resistance » Volume 3

Multidrug and extensively drug-resistant tuberculosis from a general practice perspective

Authors Yashodhara B, Huat CB, Naik LN, Umakanth S, Hande M, Pappachan JM

Published 22 October 2010 Volume 2010:3 Pages 115—122

DOI https://doi.org/10.2147/IDR.S10743

Review by Single-blind

Peer reviewer comments 2

BM Yashodhara1, Choo Beng Huat1, Lakshmi Nagappa Naik1, Shashikiran Umakanth2, Manjunatha Hande2, Joseph M Pappachan3
1Department of Medicine, Melaka Manipal Medical College, Melaka, India; 2Department of Medicine, Kasturaba Medical College, Manipal; 3Department of Medicine, Kottayam Medical College, Kerala, India

Abstract: Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the main causes for development of drug resistance. Directly observed therapy, short-course (DOTS) is the World Health Organization (WHO) strategy for worldwide eradication of tuberculosis, and our country achieved 100% coverage for DOTS through the Revised National Tuberculosis Control Program in 2006. For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy. Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases. This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

Keywords: multidrug-resistant, extensively drug-resistant, tuberculosis, general practice

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]