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Multidisciplinary Team Management of Severe Hemophilia A with Non-ST Elevation Myocardial Infarction

Authors Peng J, Yang H, Li J, Dai F, Wu J, Zhao X, Zheng C

Received 29 October 2020

Accepted for publication 12 January 2021

Published 27 January 2021 Volume 2021:14 Pages 15—20


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas

Jie Peng,1 Hongbin Yang,1 Jie Li,1 Feng Dai,1 Jingsheng Wu,2 Xielan Zhao,1 Changcheng Zheng2

1Department of Hematology, Xiangya Hemophilia Diagnosis and Treatment Center, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei, People’s Republic of China

Correspondence: Xielan Zhao
Department of Hematology, Xiangya Hemophilia Diagnosis and Treatment Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, People’s Republic of China
Tel +86-731-84327564
Fax +86-731-84327497
Changcheng Zheng
Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, 17 Lujiang Road, Hefei 230001, People’s Republic of China
Tel/Fax +86-551-62283114

Abstract: Elderly patients with hemophilia A have an increased risk of age-related thrombotic diseases, such as myocardial infarction. The relevant risk factors are comparable to those in the normal elderly population. However, their diagnosis and treatment are difficult. We report a case of a 53-year-old man with severe hemophilia A who presented with non-ST elevation myocardial infarction (NSTEMI), and this is the first report of successful treatment of such a patient in China. The patient presented with chest tightness, palpitations, and dyspnea after excessive alcohol consumption. He developed hypotension and shock, which rapidly progressed to respiratory and cardiac arrest and loss of consciousness. Immediate cardiopulmonary resuscitation was initiated, along with respiratory and cardiovascular management. Hematologic management with factor VIII (FVIII) replacement therapy and concurrent aspirin coupled with enoxaparin sodium, were also employed. As the patient’s condition was diagnosed as acute NSTEMI, a percutaneous coronary intervention was not performed. The patient showed significant improvement after 1 month; he was able to walk independently and was discharged. Based on the medication order, the patient was continuously treated with FVIII prophylaxis, clopidogrel tablets, and atorvastatin tablets after discharge to prevent the recurrence of cardiovascular events. The acute coronary syndrome incidence rate is similar in patients with hemophilia and the general population. Multidisciplinary collaborative management is required. The multidisciplinary team needs to develop its diagnosis and treatment process flow, and treatment should be individualized using or anticoagulation/antiplatelet therapy based on the patient’s medical history.

Keywords: factor replacement therapy, anticoagulation therapy, antiplatelet therapy, coagulation factors, elderly, case report

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