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More than 9 years of continuous trastuzumab treatment in metastatic breast cancer without cardiac toxicity: a case report and literature review

Authors Badulescu F, Badulescu A, Paul D, Popescu CF, Florescu C

Received 13 June 2014

Accepted for publication 12 August 2014

Published 17 October 2014 Volume 2014:7 Pages 1911—1917


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Faris Farassati

Florin Badulescu,1 Adriana Badulescu,2 Doru Paul,3 Carmen Florina Popescu,4 Cristina Florescu5

1Department of Oncology, Universitatea de Medicina si Farmacie, Craiova, Romania; 2Department of Surgery, Universitatea Titu Maiorescu, Bucuresti, Romania; 3Monter Cancer Center, North Shore LIJ Cancer Institute, Lake Success, NY, USA; 4Department of Pathology, Spitalul Universitar Clinic de Urgenta, Craiova, Romania; 5Department of Cardiology, Universitatea de Medicina si Farmacie, Craiova, Romania

Abstract: The main concern of long-term use of trastuzumab remains its association with potential cardiac side effects. Although these side effects are real, they are probably overemphasized. We report the case of a woman with metastatic breast cancer, who is currently in complete remission, and who received trastuzumab continuously for more than 9 years, without any significant cardiac toxicity.

Keywords: metastatic breast cancer, long survival, trastuzumab

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