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Monitoring of tumor vascular normalization: the key points from basic research to clinical application

Authors Li W, Quan Y, Li Y, Lu L, Cui M

Received 19 May 2018

Accepted for publication 13 July 2018

Published 3 October 2018 Volume 2018:10 Pages 4163—4172

DOI https://doi.org/10.2147/CMAR.S174712

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Wei Li,1 Ying-Yao Quan,2 Yong Li,3 Ligong Lu,3 Min Cui1

1Department of General Surgery, Zhuhai People’s Hospital, Jinan University, Zhuhai, Guangdong, People’s Republic of China; 2Department of Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, Guangdong, People’s Republic of China; 3Department of Intervention, Zhuhai People’s Hospital, Jinan University, Zhuhai, Guangdong, People’s Republic of China

Abstract: Tumor vascular normalization alleviates hypoxia in the tumor microenvironment, reduces the degree of malignancy, and increases the efficacy of traditional therapy. However, the time window for vascular normalization is narrow; therefore, how to determine the initial and final points of the time window accurately is a key factor in combination therapy. At present, the gold standard for detecting the normalization of tumor blood vessels is histological staining, including tumor perfusion, microvessel density (MVD), vascular morphology, and permeability. However, this detection method is almost unrepeatable in the same individual and does not dynamically monitor the trend of the time window; therefore, finding a relatively simple and specific monitoring index has important clinical significance. Imaging has long been used to assess changes in tumor blood vessels and tumor changes caused by the oxygen environment in clinical practice; some preclinical and clinical research studies demonstrate the feasibility to assess vascular changes, and some new methods were in preclinical research. In this review, we update the most recent insights of evaluating tumor vascular normalization.

Keywords: angiogenesis, vascular normalization, time window

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