Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Molecular targets in arthritis and recent trends in nanotherapy

Authors Roy K, Kanwar R, Kanwar J

Received 24 May 2015

Accepted for publication 8 July 2015

Published 26 August 2015 Volume 2015:10(1) Pages 5407—5420

DOI https://doi.org/10.2147/IJN.S89156

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Preety Sahdev

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster

Kislay Roy, Rupinder Kaur Kanwar, Jagat Rakesh Kanwar

Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), Centre for Molecular and Medical Research (C-MMR), Strategic Research Centre, School of Medicine (SoM), Faculty of Health, Deakin University, Waurn Ponds, VIC, Australia

Abstract: Due to its severity and increasing epidemiology, arthritis needs no description. There are various forms of arthritis most of which are disabling, very painful, and common. In spite of breakthroughs in the field of drug discovery, there is no cure for arthritis that can eliminate the disease permanently and ease the pain. The present review focuses on some of the most successful drugs in arthritis therapy and their side effects. Potential new targets in arthritis therapy such as interleukin-1β, interleukin-17A, tumor necrosis factor alpha, osteopontin, and several others have been discussed here, which can lead to refinement of current therapeutic modalities. Mechanisms for different forms of arthritis have been discussed along with the molecules that act as potential biomarkers for arthritis. Due to the difficulty in monitoring the disease progression to detect the advanced manifestations of the diseases, drug-induced cytotoxicity, and problems with drug delivery; nanoparticle therapy has gained the attention of the researchers. The unique properties of nanoparticles make them highly attractive for the design of novel therapeutics or diagnostic agents for arthritis. The review also focuses on the recent trends in nanoformulation development used for arthritis therapy. This review is, therefore, important because it describes the relevance and need for more arthritis research, it brings forth a critical discussion of successful drugs in arthritis and analyses the key molecular targets. The review also identifies several knowledge gaps in the published research so far along with the proposal of new ideas and future directions in arthritis therapy.

Keywords: osteoarthritis, rheumatoid arthritis, interleukin, osteopontin, nanoparticle, bovine lactoferrin

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2017, 11:2683-2684

Published Date: 12 September 2017

Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers

Kamalapuram SK, Kanwar RK, Roy K, Chaudhary R, Sehgal R, Kanwar JR

International Journal of Nanomedicine 2016, 11:1349-1366

Published Date: 1 April 2016

Biodegradable Eri silk nanoparticles as a delivery vehicle for bovine lactoferrin against MDA-MB-231 and MCF-7 breast cancer cells

Roy K, Patel YS, Kanwar RK, Rajkhowa R, Wang X, Kanwar JR

International Journal of Nanomedicine 2016, 11:25-44

Published Date: 21 December 2015

Neurobehavioral burden of multiple sclerosis with nanotheranostics

Sriramoju B, Kanwar RK, Kanwar JR

Neuropsychiatric Disease and Treatment 2015, 11:2675-2689

Published Date: 15 October 2015

Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii

Anand N, Sehgal R, Kanwar RK, Dubey ML, Vasishta RK, Kanwar JR

International Journal of Nanomedicine 2015, 10:6355-6369

Published Date: 8 October 2015

Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction

Anand N, Kanwar RK, Dubey ML, Vahishta RK, Sehgal R, Verma AK, Kanwar JR

Drug Design, Development and Therapy 2015, 9:3821-3835

Published Date: 27 July 2015

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2015, 9:2927-2940

Published Date: 5 June 2015

Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model

Roy K, Kanwar RK, Krishnakumar S, Cheung CH, Kanwar JR

International Journal of Nanomedicine 2015, 10:1019-1043

Published Date: 2 February 2015

Nanoformulated cell-penetrating survivin mutant and its dual actions

Sriramoju B, Kanwar RK, Kanwar JR

International Journal of Nanomedicine 2014, 9:3279-3298

Published Date: 10 July 2014

Neurological disorders and therapeutics targeted to surmount the blood–brain barrier

Kanwar JR, Sriramoju B, Kanwar RK

International Journal of Nanomedicine 2012, 7:3259-3278

Published Date: 9 July 2012

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010