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Molecular Mechanisms of Anticancer Activities of Puerarin

Authors Ahmad B, Khan S, Liu Y, Xue M, Nabi G, Kumar S, Alshwmi M, Qarluq AW

Received 5 October 2019

Accepted for publication 16 December 2019

Published 8 January 2020 Volume 2020:12 Pages 79—90

DOI https://doi.org/10.2147/CMAR.S233567

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Bashir Ahmad,1,* Suliman Khan,2,3,* Yang Liu,2,3 Mengzhou Xue,2,3 Ghulam Nabi,4 Sunjeet Kumar,5 Mohammed Alshwmi,6 Abdul Wakeel Qarluq7

1Department of Pathology and Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 2The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 3Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, People’s Republic of China; 4Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, People’s Republic of China; 5The Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People’s Republic of China; 6Department of Clinical Laboratory, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 7Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Mengzhou Xue; Ghulam Nabi Email xuemengzhou@zzu.edu.cn; ghulamnabiqau@gmail.com

Abstract: Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment.

Keywords: medicinal plants, natural products, Puerarin, Pueraria lobata, Pueraria thomsonii, Pueraria tuberosa

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