Back to Journals » Hypoxia » Volume 2

Modulation of hydrogen sulfide by vascular hypoxia

Authors Osmond J, Kanagy N

Received 30 April 2014

Accepted for publication 4 June 2014

Published 25 August 2014 Volume 2014:2 Pages 117—126

DOI https://doi.org/10.2147/HP.S51589

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3


Jessica M Osmond, Nancy L Kanagy

Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

Abstract: Hydrogen sulfide (H2S) has emerged as a key regulator of cardiovascular function. This gasotransmitter is produced in the vasculature and is involved in numerous processes that promote vascular homeostasis, including vasodilation and endothelial cell proliferation. Although H2S plays a role under physiological conditions, it has become clear in recent years that hypoxia modulates the production and action of H2S. Furthermore, there is growing evidence that H2S is cytoprotective in the face of hypoxic insults. This review focuses on the synthesis and signaling of H2S in hypoxic conditions in the vasculature, and highlights recent studies providing evidence that H2S is a potential therapy for preventing tissue damage in hypoxic conditions.

Keywords: H2S, cystathionine γ-lyase, vascular smooth muscle, endothelium

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]