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Models of intrahepatic cholangiocarcinoma: novel tools and therapeutic applications

Authors Hill MA, Alexander WB, Hezel AF

Received 18 April 2017

Accepted for publication 25 October 2017

Published 19 February 2018 Volume 2018:8 Pages 1—11

DOI https://doi.org/10.2147/GICTT.S115757

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Margaret A Hill,1,2,* William B Alexander,1,2,* Aram F Hezel1,2

1Department of Biomedical Genetics, 2Department of Medicine, Hematology/Oncology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA

*These authors contributed equally to this work

Abstract: Intrahepatic cholangiocarcinoma (iCCA) is the second most common hepatic malignancy, and a number of recent studies have identified an increasing trend in incidence and mortality. As an aggressive disease characterized by early metastasis, surgical resection is not an option for most patients, and chemotherapy has limited benefit. Thus, the prognosis is extremely poor, warranting the development of novel models to improve detection and treatment strategies for this lethal cancer. In this regard, significant technological advancements have provided key tools to model and study iCCA. Furthermore, these technologies are addressing the need for models that can readily be adapted to address different genetic contexts, an important consideration for genetically diverse cancers such as iCCA. In this review, we outline these various available tools, discussing specifically how they have been employed to study iCCA while highlighting important therapeutic implications. Finally, we discuss novel strategies utilizing patient-derived tumor tissue which have promising translational applications.

Keywords: cholangiocarcinoma, biliary cancer, models, cell of origin, Cre-Lox, sleeping beauty

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