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Modafinil: a novel alternative to non-invasive ventilation in hypercapnic respiratory failure?


Authors Matos P, Esquinas A

Received 26 February 2015

Accepted for publication 26 February 2015

Published 1 April 2015 Volume 2015:10(1) Pages 711—713

DOI https://doi.org/10.2147/COPD.S83558

Checked for plagiarism Yes

Editor who approved publication: Dr Richard Russell

Paulo Matos,1 Antonio M Esquinas2

1Pneumology Department, Hospitais da Universidade de Coimbra, Coimbra, Portugal; 2Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain

Nowadays non-invasive ventilation (NIV) is a common therapeutic option in chronic hypercapnic respiratory failure, especially in chronic obstructive pulmonary disease (COPD).1 Even though there is not robust data showing mortality or morbidity benefits, it appears to improve quality of life and reduce admissions for exacerbation.1,2 However, there will always be a group of patients where NIV is not an option, because of poor compliance or side effects. 


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