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MiR-326: Promising Biomarker for Cancer

Authors Pan YJ, Wan J, Wang CB

Received 19 July 2019

Accepted for publication 2 December 2019

Published 11 December 2019 Volume 2019:11 Pages 10411—10418

DOI https://doi.org/10.2147/CMAR.S223875

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Eileen O'Reilly


Yao-Jie Pan,1 Jian Wan,2 Chun-Bin Wang1

1Department of Oncology, The Affiliated Yancheng Hospital of Medicine School of Southeast University, The Third People’s Hospital of Yancheng, Yancheng 224001, People’s Republic of China; 2Department of General Surgery, Center for Difficult and Complicated Abdominal Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, People’s Republic of China

Correspondence: Chun-Bin Wang
Department of Oncology, The Affiliated Yancheng Hospital of Medicine School of Southeast University, The Third People’s Hospital of Yancheng, 75 Juchang Road, Yancheng, Jiangsu 224001, People’s Republic of China
Tel +86-515-81606113
Email yclvwenping@163.com

Abstract: MicroRNAs (miRNAs) are small non-coding and highly conserved RNAs that act in biological processes including cell proliferation, invasion, apoptosis, metabolism, signal transduction, and tumorigenesis. The previously identified miRNA-326 (miR-326) has been reported to participate in cellular apoptosis, tumor growth, cell invasion, embryonic development, immunomodulation, chemotherapy resistance, and oncogenesis. This review presents a detailed overview of what is known about the effects of miR-326 on cell invasion, metastasis, drug resistance, proliferation, apoptosis, and its involvement in signaling pathways.

Keywords: MicroRNA, miR-326, tumor suppressor, cancer, metastasis, oncogene

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