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miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis

Authors Ye H, Hao H, Wang J, Chen R, Huang Z

Received 8 February 2017

Accepted for publication 22 May 2017

Published 21 July 2017 Volume 2017:10 Pages 3685—3696

DOI https://doi.org/10.2147/OTT.S134252

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz

Huajun Ye,1,* Haibin Hao,2,* Jincheng Wang,3 Renpin Chen,1 Zhiming Huang1

1Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, 2Department of General Surgery, Medical College of Nanchang University, Nanchang, 3Department of Medical Imaging, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China

*These authors contributed equally to this work

Abstract: We sought to systematically evaluate the diagnostic and prognostic value of miR-203 in patients with colorectal cancer. To explore the diagnostic performance of miR-203, eligible studies were identified from biomedical databases. Based on these results, 11 studies were pooled and included in this meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratios of miR-203 were 0.83 (95% confidence interval, CI: 0.78–0.86), 0.80 (95% CI: 0.77–0.83), and 19.27 (95% CI: 7.23–51.36) for the diagnosis of colorectal cancer. The area under the curve for miR-203 for diagnosing colorectal cancer was 0.89. Patients with higher expression of tissue miR-203 had poor overall survival (pooled hazard ratio: 1.63; 95% CI: 1.03–2.57, P=0.04), but serum miR-203 was not predictive (pooled hazard ratio: 1.59; 95% CI: 0.31–8.12, P=0.58). The miR-203 values of tissue and serum merged together may perhaps predict superior overall survival (pooled hazard ratio: 1.62; 95% CI: 0.93–2.82), but the effect was not significant (P=0.09).

Keywords: colorectal cancer, CRC, diagnosis, miR-203, prognosis

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