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miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer

Authors Fesler A, Zhai H, Ju J

Received 5 April 2014

Accepted for publication 15 May 2014

Published 21 August 2014 Volume 2014:7 Pages 1481—1485

DOI https://doi.org/10.2147/OTT.S65548

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Andrew Fesler, Haiyan Zhai, Jingfang Ju

Department of Pathology, Stony Brook Medicine, Stony Brook University, Stony Brook, NY, USA

Abstract: In the last decade, cancer research efforts in the field of noncoding microRNA (miRNA) have been growing exponentially. miRNA-based therapeutics have been tested in both preclinical and clinical settings, and miRNA-based cancer diagnostics and prognostics have moved into clinics to help better manage cancer treatment. A growing body of evidence in recent literature suggests miRNA-129 plays important roles in gastrointestinal cancer, including gastric, colorectal, hepatocellular carcinoma, and esophageal cancer. In this review, we focus on accumulating evidence demonstrating the key roles that miRNA-129 plays in tumorigenesis, disease progression, chemoresistance, proliferation, and cell cycle control. Understanding the emerging roles and mechanisms of miRNA-129 in cancer will help us realize the therapeutic and diagnostic/prognostic potential.

Keywords: miR-129, cancer, therapeutics, biomarker, 5-FU

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