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MIOTIC study: a prospective, multicenter, randomized study to evaluate the long-term efficacy of mobile phone-based Internet of Things in the management of patients with stable COPD

Authors Zhang J, Song Y, Bai C

Received 19 June 2013

Accepted for publication 1 August 2013

Published 19 September 2013 Volume 2013:8 Pages 433—438

DOI https://doi.org/10.2147/COPD.S50205

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Jing Zhang, Yuan-lin Song, Chun-xue Bai

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China

Abstract: Chronic obstructive pulmonary disease (COPD) is a common disease that leads to huge economic and social burden. Efficient and effective management of stable COPD is essential to improve quality of life and reduce medical expenditure. The Internet of Things (IoT), a recent breakthrough in communication technology, seems promising in improving health care delivery, but its potential strengths in COPD management remain poorly understood. We have developed a mobile phone-based IoT (mIoT) platform and initiated a randomized, multicenter, controlled trial entitled the ‘MIOTIC study’ to investigate the influence of mIoT among stable COPD patients. In the MIOTIC study, at least 600 patients with stable GOLD group C or D COPD and with a history of at least two moderate-to-severe exacerbations within the previous year will be randomly allocated to the control group, which receives routine follow-up, or the intervention group, which receives mIoT management. Endpoints of the study include (1) frequency and severity of acute exacerbation; (2) symptomatic evaluation; (3) pre- and post-bronchodilator forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) measurement; (4) exercise capacity; and (5) direct medical cost per year. Results from this study should provide direct evidence for the suitability of mIoT in stable COPD patient management.

Keywords: Internet of Things, mobile phone, chronic obstructive pulmonary disease, efficacy

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