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Minor Physical Anomalies Among Schizophrenic Patients as a Biomarker of Its Developmental Origin in Northwest Ethiopia

Authors Tsehay B, Shitie D

Received 12 August 2020

Accepted for publication 23 October 2020

Published 28 October 2020 Volume 2020:16 Pages 2491—2497

DOI https://doi.org/10.2147/NDT.S275582

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Binalfew Tsehay, Desalegn Shitie

Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia

Correspondence: Binalfew Tsehay Department of Biomedical Sciences
Debre Markos University, P. O. Box 269, Debre Markos, Ethiopia
Tel +251 910287723
Email bunadmu@gmail.com

Purpose: Although there are highly precise and advanced diagnostic methods, the etiology and pathophysiology of schizophrenia remain poorly understood. There are several theories about schizophrenia origin, among which the neurodevelopmental theory is widely accepted. Our study aimed to assess minor physical anomalies among schizophrenic patients as putative indices of its developmental origin in North West Ethiopia 2018– 2019.
Patients and Methods: Institutional-based comparative cross-sectional study design was conducted in Debre Markos comprehensive, specialized hospitals in 190 schizophrenic patients, 190 healthy controls, and 190 1st-degree relatives. Data were collected using standard methods, entered into EpiData version 3.1, and exported to SPSS version 24 for analysis. Descriptive data were analyzed using descriptive statistics, and discriminant function analysis was conducted and a value of 0.03 was taken as the cutoff point for prediction of group status of the study samples.
Results: Five hundred seventy study samples, male 375 (65.8%), and female 195 (34.2%), were included in this study. The discriminate function 1 and 2 revealed a significant association between groups and all predictors, accounting for 83.5% and 16.5% of between-group variability, respectively. However, closer analysis of the structure matrix revealed longitudinally furrowed tongue, ≥Five palate ridges, high steeples palate, transversely and randomly furrowed tongue, protruding supraorbital ridge as significant predictors.
Conclusion: Depending on predictor variables in this study, minor physical anomalies can serve as a biomarker for early screening of schizophrenic patients and clue for its developmental origin.

Keywords: minor physical anomalies, schizophrenia, neurodevelopment, Ethiopia

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