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Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines

Authors Yang J, Yu Y, Liu W, Li Z, Wei ZQ, Jiang R

Received 4 August 2016

Accepted for publication 13 December 2016

Published 8 May 2017 Volume 2017:9 Pages 71—77

DOI https://doi.org/10.2147/RRU.S118966

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Jan Colli


Jian Yang,1,2,* Yang Yu,1,* Wei Liu,2 Zhi Li,2 Zhongqing Wei,2 Rongjiang Jiang1,2

1The Second Clinical Medical College of Nanjing Medical University, 2Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China

*These authors contributed equally to this work.

Abstract: Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recurrent prostate cancer cells after docetaxel treatment have higher levels of microtubule-associated protein tau. In vitro, inactivation of tau by gene knockdown suppressed cell proliferation and sensitized docetaxel cytotoxicity. Also, our results demonstrated that the PI3K/Akt/mTOR pathway was upregulated in DU145 docetaxel-resistant cells compared with the DU145-naïve cells. Thus, targeting tau protein and PI3K/Akt/mTOR pathway are promising strategies to enhance docetaxel response for the treatment of prostate cancer.

Keywords: prostate cancer, microtubule-associated protein tau, docetaxel resistance, tau protein, PI3K/Akt/mTOR pathway

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