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MicroRNA And Circular RNA Expression In Affected Skin Of Patients With Postherpetic Neuralgia

Authors Cao S, Zhang D, Yuan J, Liu C, Zhou W, Zhang L, Yu S, Qin B, Li Y, Deng W

Received 2 July 2019

Accepted for publication 30 September 2019

Published 16 October 2019 Volume 2019:12 Pages 2905—2913

DOI https://doi.org/10.2147/JPR.S221615

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Michael Ueberall


Song Cao,1,2 Dexin Zhang,1 Jie Yuan,1,2 Chengxi Liu,2 Wenjing Zhou,2 Lin Zhang,2 Shouyang Yu,2 Bangyong Qin,1 Ying Li,1 Wenwen Deng3

1Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, People’s Republic of China; 2Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi 563003, People’s Republic of China; 3Department of Cardiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, People’s Republic of China

Correspondence: Song Cao
Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, People’s Republic of China
Tel +8618212170434 Email caosong4321@163.com
 
Wenwen Deng
Department of Cardiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, People’s Republic of China
Tel +8615085064354
Email 912395627@qq.com

Abstract: Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affected skin and the mirror skin were collected and subjected to miRNA and circRNA microarray, and expression profiles were comparatively analyzed. There were 317 differently expressed miRNAs in PHN affected skin compared with mirror skin (fold change ≥2.0), and 13 of them showed fold change >10 in the PHN skin. Only one circRNA, hsa_circRNA_405463 showed fold change >2 in PHN skin, however, 31 circRNAs with fold change ≥1.5. To evaluate functions of differential miRNAs, their target mRNAs were predicted and bioinformatics analyses including gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway were conducted. Target mRNAs significantly (P<0.05) enriched in 85 pathways, such as FoxO, AMPK, MAPK and pathway. These data reported for the first time that miRNA and circRNA differentially expressed in the PHN skin and these transcripts with abnormal expression could be potential targets to treat PHN.

Keywords: neuropathic pain, postherpetic neuralgia, microRNA, circular RNA


 

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