Back to Journals » International Journal of Nanomedicine » Volume 4

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Authors Samei E, Saunders RS, Badea CT, Ghaghada KB, Hedlund LW, Qi Y, Yuan H, Bentley RC, Mukundan Jr S

Published 19 November 2009 Volume 2009:4 Pages 277—282


Review by Single-blind

Peer reviewer comments 3

Ehsan Samei1,2,3,4, Robert S Saunders1, Cristian T Badea2,5, Ketan B Ghaghada2,5†, Laurence W Hedlund2,5, Yi Qi2,5, Hong Yuan6, Rex C Bentley7, Srinivasan Mukundan Jr2,3,5*

1Carl E Ravin Advanced Imaging Laboratories, 2Department of Radiology, 3Department of Biomedical Engineering, 4Department of Physics, 5Center for In Vivo Microscopy, 6Department of Radiation Oncology, 7Department of Pathology, Duke University, Durham, NC, USA; Current address: School of Health Information Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA; *Current address: Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA

Abstract: A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.

Keywords: molecular imaging, liposome, angiogenesis, breast cancer, small animal imaging, micro-CT

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Dry powder cationic lipopolymeric nanomicelle inhalation for targeted delivery of antitubercular drug to alveolar macrophage

Vadakkan MV, Annapoorna K, Sivakumar KC, Mundayoor S, Kumar GSV

International Journal of Nanomedicine 2013, 8:2871-2885

Published Date: 7 August 2013

Echographic detectability of optoacoustic signals from low-concentration PEG-coated gold nanorods

Conversano F, Soloperto G, Greco A, Ragusa A, Casciaro E, Chiriacò F, Demitri C, Gigli G, Maffezzoli A, Casciaro S

International Journal of Nanomedicine 2012, 7:4373-4389

Published Date: 9 August 2012

Development of 3D in vitro platform technology to engineer mesenchymal stem cells

Hosseinkhani H, Hong P, Yu D, Chen Y, Ickowicz D, Farber I, Domb AJ

International Journal of Nanomedicine 2012, 7:3035-3043

Published Date: 29 June 2012

DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes

Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N

International Journal of Nanomedicine 2011, 6:2689-2695

Published Date: 4 November 2011

Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering

Hajiali H, Shahgasempour S, Naimi-Jamal MR, Peirovi H

International Journal of Nanomedicine 2011, 6:2133-2141

Published Date: 27 September 2011

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

Tan W, Li YB, Chen MW, Wang YT

International Journal of Nanomedicine 2011, 6:1773-1777

Published Date: 24 August 2011

Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo

Zhao JH, Ji L, Wang H, Chen ZQ, Zhang YT, Liu Y, Feng NP

International Journal of Nanomedicine 2011, 6:1611-1619

Published Date: 9 August 2011

Preparation and characterization of low-molecular-weight heparin/protamine nanoparticles (LMW-H/P NPs) as FGF-2 carrier

Yasutaka Mori, Shingo Nakamura, Satoko Kishimoto, et al

International Journal of Nanomedicine 2010, 5:147-155

Published Date: 11 March 2010

Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis

Kazuo Yudoh, Rie Karasawa, Kayo Masuko, et al

International Journal of Nanomedicine 2009, 4:233-239

Published Date: 20 October 2009

Near infrared planar tumor imaging and quantification using nanosized Alexa 750-labeled phospholipid micelles

Aristarchos Papagiannaros, Amit Kale, Tatyana S Levchenko, Dmitry Mongayt, et al.

International Journal of Nanomedicine 2009, 4:123-131

Published Date: 19 May 2009