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Metronome-Paced Incremental Hyperventilation May Predict Exercise Tolerance and Dyspnea as a Surrogate for Dynamic Lung Hyperinflation During Exercise

Authors Kawachi S, Fujimoto K

Received 21 January 2020

Accepted for publication 3 May 2020

Published 15 May 2020 Volume 2020:15 Pages 1061—1069

DOI https://doi.org/10.2147/COPD.S246850

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell


Shohei Kawachi,1 Keisaku Fujimoto2

1Department of Biomedical Laboratory Science, Graduate School of Medicine, Shinshu University, Nagano 390-8621, Japan; 2Department of Clinical Laboratory Sciences, Shinshu University School of Health Sciences, Nagano 390-8621, Japan

Correspondence: Keisaku Fujimoto Email keisaku@shinshu-u.ac.jp

Background: Dynamic lung hyperinflation (DLH) has been evaluated based on decreased inspiratory capacity (IC) during exercise load. However, this is not routinely done in clinical practice. We have developed a convenient method of metronome-paced incremental hyperventilation (MPIH) and reported its usefulness. In the present study, we compared these two methods for evaluating DLH and examined whether our MPIH method can be used to predict DLH during exercise.
Methods: DLH was measured by MPIH and constant load exercise (CLE) in 35 patients with stable COPD. DLH was defined as the most decreased IC (IClowest) and the most decreases in IC from IC at rest (−IClowest), and we compared between these two methods.
Results: The IClowest in CLE and the −IClowest in MPIH were significantly lower in emphysema-dominant COPD than in emphysema-nondominant COPD. Both IClowest and −IClowest showed significant correlations between the two methods (r = 0.67, p < 0.01 and r = 0.44, p < 0.01, respectively). The endurance time of CLE was significantly correlated with IClowest following MPIH (r = 0.62, p < 0.01) but not with that obtained by the CLE method. Furthermore, the IClowest of MPIH was more significantly correlated with endurance time in emphysema-dominant COPD. Weak but significant correlations between the −IClowest obtained by each method and maximum modified Borg scale were observed (MPIH: r = 0.38, p = 0.02; CLE: r = 0.37, p = 0.03).
Conclusion: The MPIH method may be a convenient method to predict exercise tolerance and dyspnea as a clinically useful synergic screening surrogate for DLH during exercise.

Keywords: dynamic lung hyperinflation, constant load exercise, hyperventilation, endurance time, inspiratory capacity


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