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Metalloproteinases as modulators of allergic asthma: therapeutic perspectives

Authors Ingram J, Kraft M

Received 15 July 2015

Accepted for publication 2 September 2015

Published 23 October 2015 Volume 2015:2 Pages 61—74


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Triparna Sen

Peer reviewer comments 3

Editor who approved publication: Dr Yoshifumi Itoh

Jennifer L Ingram,1 Monica Kraft2

1Department of Medicine, Duke University, Durham, NC, 2Department of Medicine, University of Arizona, Tucson, AZ, USA

Abstract: Matrix metalloproteinases (MMPs) are proteolytic enzymes that facilitate extracellular matrix turnover; thus, these enzymes are important in both normal wound repair and pathologic processes, such as inflammation and fibrosis. In addition, MMPs regulate cell signaling through proteolytic shedding of bioactive growth factors, cytokines, and other molecules. Therefore, the expression and activation of MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases, play roles in the development of a variety of diseases. Allergic asthma is a chronic inflammatory disease of the airways that affects millions of patients, both children and adults, worldwide. Allergen-induced airway injury and immune responses stimulate airway inflammation, hyperresponsiveness, and remodeling in these patients. The action of MMPs links these pathologic processes through a complex interaction of airway inflammatory cells and structural cells. This review explores the important roles of MMPs and tissue inhibitors of metalloproteinases in mediating the pathobiology of allergic asthma and highlights the potential for these enzymes to serve as biomarkers or therapeutic targets in allergic asthma.

Keywords: matrix metalloproteinase, MMP, asthma, allergy, airway

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