Back to Journals » Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy » Volume 12

Metabolic syndrome as a risk factor for high intraocular pressure: the Korea National Health and Nutrition Examination Survey 2008–2010

Authors Yi YH, Cho YH, Kim YJ, Lee SY, Lee JG, Kong EH, Cho BM, Tak YJ, Hwang HR, Lee SH, Park EJ

Received 28 August 2018

Accepted for publication 22 December 2018

Published 14 January 2019 Volume 2019:12 Pages 131—137


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Steven F. Abcouwer

Yu Hyeon Yi,1,2 Young Hye Cho,3 Yun Jin Kim,1,2 Sang Yeoup Lee,3 Jeong Gyu Lee,1,2 Eun Hee Kong,4 Byung Mann Cho,5 Young Jin Tak,1,2 Hye Rim Hwang,1,2 Seung Hun Lee,1,2 Eun Ju Park3

1Department of Family Medicine, Pusan National University School of Medicine, Yangsan 626-780, Korea; 2Department of Family Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, Korea; 3Department of Family Medicine, Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626–780, Korea; 4Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea; 5Department of Preventive Medicine, Pusan National University School of Medicine, Yangsan 626-780, Korea

Background: High intraocular pressure (IOP) is well established as the most significant risk factor for both the development and progression of primary open-angle glaucoma. Elevated IOP is more frequently seen in the presence of metabolic disturbances that are associated with the components of metabolic syndrome (MetS). The aim of this study was to investigate the association between ocular hypertension and MetS.
Patients and methods: We examined the relationship between ocular hypertension and MetS in 17,160 Korean adults without glaucoma aged >19 years (7,368 men and 9,792 women) who participated in the 2008–2010 Korea National Health and Nutrition Examination Survey. Multivariate logistic regression analysis was used to assess the relationship between MetS and ocular hypertension, after adjusting for age, body mass index, smoking, alcohol consumption, and regular exercise.
Results: The prevalence of MetS was 35.1% among males and 30.1% among females. The prevalence of ocular hypertension was 1.3% among males with MetS and 0.7% among females with MetS. Participants with MetS had a significantly higher IOP than those without MetS (P≤0.001), and each component of MetS had a different effect on the IOP. Hypertension was the strongest predictor of an elevated IOP. In multivariate regression analysis, ocular hypertension was significantly associated with MetS (P=0.027 for men; P=0.015 for women).
Conclusion: There is a statistically significant relationship between MetS and ocular hypertension.

Keywords: intraocular pressure, glaucoma, metabolic syndrome, obesity, hypertension

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]