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Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors

Authors Zu G, Luo B, Yang Y, Tan Y, Tang T, Zhang Y, Chen X, Sun D

Received 12 October 2018

Accepted for publication 28 December 2018

Published 26 February 2019 Volume 2019:11 Pages 1881—1892

DOI https://doi.org/10.2147/CMAR.S190510

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Guangchen Zu,1,* Baoyang Luo,2,* Yong Yang,1 Yuwei Tan,1 Tianyu Tang,1 Yue Zhang,1 Xuemin Chen,1 Donglin Sun1

1Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China; 2Department of Hepatobiliary Surgery, Taizhou People’s Hospital, Taizhou 225300, People’s Republic of China

*These authors contributed equally to this work

Background: Expression of C-C chemokine receptor type 7 (CCR7) is associated with the prognosis of several cancers. The aim of this study was to conduct the meta-analysis to determine the prognostic value of CCR7 expression in solid tumors.
Materials and methods: We searched for relevant literature in the PubMed, Embase, and Cochrane Library databases (last updated on January 15, 2018). The associations of CCR7 expression with overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS), progress-free survival (PFS), and disease-specific survival (DSS) were estimated.
Results: In total, 30 qualified studies including 3,413 patients were enrolled. The results revealed that higher expression of CCR7 predicted poorer OS (pooled HR =1.79; 95% CI =1.49–2.16; P<0.001) and PFS (pooled HR =2.18; 95% CI =1.49–3.18; P<0.001), but was not associated with DFS (pooled HR =1.69; 95% CI =0.79–3.61; P=0.175), RFS (pooled HR =1.29; 95% CI =0.48–3.44; P=0.618), or DSS (pooled HR =3.06; 95% CI =0.38–24.83; P<0.294).
Conclusion: From this meta-analysis, we concluded that high expression of CCR7 in tumor tissue is associated with poor survival in patients with solid tumors, and may be a prognostic biomarker for tumor progression.

Keywords: CCR7, solid tumors, prognosis, systematic review, meta-analysis
 

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