Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER
Michael Birnbaum1, Zafar Sharif2
1St. Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Ave, New York, NY, USA; 2Columbia University College of Physicians and Surgeons, New York, NY, USA
Abstract: Antipsychotic medications provide the foundation for treatment of acute exacerbations as well as relapse prevention in patients with schizophrenia as demonstrated by rigorous placebo-controlled trials. However, despite their proven effectiveness, poor adherence to prescribed antipsychotic regimens remains the most important driver of suboptimal clinical outcomes in this population. This paper reviews the magnitude of the problem of medication non-adherence in patients with schizophrenia and the various factors that contribute to nonadherence, with particular emphasis on factors related to antipsychotic medications. The profile of the latest atypical antipsychotic, paliperidone extended-release (ER) tablets, is then reviewed and the implications of its unique pharmacokinetic profile for adherence in this patient population are discussed.
Keywords: schizophrenia, adherence, paliperidone, pharmacokinetics
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