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Mediating Effect Of The Motivation For Medication Use On Disease Management And Medication Adherence Among Community-Dwelling Patients With Schizophrenia

Authors Hsieh WL, Lee SK, Chien WT, Liu WI, Lai CY, Liu CY

Received 10 June 2019

Accepted for publication 19 October 2019

Published 5 November 2019 Volume 2019:13 Pages 1877—1887

DOI https://doi.org/10.2147/PPA.S218553

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen


Wen Ling Hsieh,1 Shih Kai Lee,2 Wai Tong Chien,3 Wen I Liu,4 Chien Yu Lai,4 Chieh Yu Liu4

1Department of Nursing, Taipei Municipal Wanfang Hospital (Managed by Taipei Medical University), Taipei City, Taiwan; 2Department of Nursing, Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou, Taiwan; 3The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; 4College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan

Correspondence: Wen I Liu
National Taipei University of Nursing and Health Sciences, No. 365, Ming-Te Road, Peitou District, Taipei City 11219, Taiwan
Tel +886 2 2822 7101 Ext. 3184
Fax +886 2 2821 3233
Email wenyi@ntunhs.edu.tw

Background: Nearly half of patients with schizophrenia do not adhere to the long-term medical treatment needed to manage their disease. Programs to promote medication adherence include promotion of motivation as a critical element to influence task performance.
Purpose: This study investigated the mediating effect of motivation for medication use on disease management and medication adherence in schizophrenia.
Methods: This cross-sectional, descriptive correlational study enrolled a convenience sample of 373 community-dwelling patients with schizophrenia in the northern and central regions of Taiwan. Data were collected with questionnaires and a series of validated assessment tools. Hierarchical regression was used to analyze the mediating effect of motivation for medication use on disease management and medication adherence.
Results: The medication adherence rate of the patients was 47.2%. The mediating effect of motivation for medication use on therapeutic alliance and medication adherence was 50%, whereas that on insight and medication adherence was 41% and that on medical social support and medication adherence was 72%.
Conclusion: Developing a medication motivation care model may be more effective than promoting therapeutic alliance, insight, or medical social support for promoting medication adherence. It also had greater impact on preventing relapses of community-dwelling patients with schizophrenia.

Keywords: cross-sectional study, medication adherence, disease management, motivation for medication use, schizophrenia, community-dwelling patients

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