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Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method

Authors Liu J, Cao J, Cao JH, Han SC, Liang Y, Bai MF, Sun Y

Received 22 December 2017

Accepted for publication 28 March 2018

Published 15 May 2018 Volume 2018:13 Pages 2839—2856

DOI https://doi.org/10.2147/IJN.S160651

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang


Jiao Liu,1,* Jie Cao,1,* Jianhua Cao,2 Shangcong Han,1 Yan Liang,1 Mingfeng Bai,3 Yong Sun1

1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China; 2Department of Pharmacy, Qingdao No 3 Hospital, Qingdao, China; 3Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

*
These authors contributed equally to this work

Introduction: Nanoparticles are increasingly used as drug carriers for oral administration. The delivery of drug molecules is largely dependent on the interaction of nanocarriers and gastrointestinal (GI) mucus, a critical barrier that regulates drug absorption. It is therefore important to understand the effects of physical and chemical properties of nanocarriers on the interaction with GI mucus. Unfortunately, most of the nanoparticles are unable to be prepared with satisfactory structural monodispersity to comprehensively investigate the interaction. With controlled size, shape, and surface chemistry, copolymers are ideal candidates for such purpose.
Materials and methods: We synthesized a series of diblock copolymers via the atom transfer radical polymerization method and investigated the GI mucus permeability in vitro and in vivo.
Results: Our results indicated that uncharged and hydrophobic copolymers exhibited enhanced GI absorption.
Conclusion: These results provide insights into developing optimal nanocarriers for oral administration.

Keywords:
absorption barriers, oral drug delivery system, ATRP, nanoparticles

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