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Mechanism of immune evasion in breast cancer

Authors Wang M, Zhang C, Song Y, Wang Z, Wang Y, Luo F, Xu Y, Zhao Y, Wu Z, Xu Y

Received 3 November 2016

Accepted for publication 17 December 2016

Published 14 March 2017 Volume 2017:10 Pages 1561—1573

DOI https://doi.org/10.2147/OTT.S126424

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 4

Editor who approved publication: Dr Ingrid Espinoza

Mozhi Wang,1,* Changwang Zhang,2,* Yongxi Song,2 Zhenning Wang,2 Yaojia Wang,1 Fang Luo,1 Yujie Xu,1 Yi Zhao,1 Zhonghua Wu,2 Yingying Xu1

1Department of Breast Surgery, 2Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China

*These authors contributed equally to this work

Abstract: Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body’s immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail.

Keywords: immune evasion, mechanism, breast cancer, cytokines, apoptosis, PD-L1

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