Measurement of the acute inflammatory response to walking exercise in COPD: effects of pulmonary rehabilitation
Authors Jane Canavan, Rachel Garrod, Johanna Marshall, David Jackson, Paula Ansley, Andy Jewell
Published 15 October 2007 Volume 2007:2(3) Pages 347—353
Jane Canavan1, Rachel Garrod1, Johanna Marshall1, David Jackson1, Paula Ansley2, Andy Jewell3
1School of Physiotherapy, Faculty of Health and Social Care Sciences, St. George’s, University of London, London, United Kingdom; 2Department of Sport and Exercise Science, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, United Kingdom; 3Radiography, Faculty of Health and Social Sciences, St. George’s, University of London, London, United Kingdom
Objective: This pilot study concerns the evaluation of the acute cytokine response to exercise and changes in this throughout a 7 week pulmonary rehabilitation programme.
Methods: 17 (10 male, 7 female) stable COPD patients, mean (SD) age 69 (8) yrs, mean FEV1, 51.3 (17.3) % predicted entered into 7 weeks of rehabilitation. The acute cytokine response (ACR) was measured from serum cytokine levels; Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) taken pre, post and 1 hour post-maximal incremental shuttle walking test (ISWT). The ACR to maximal exercise was determined before rehabilitation (T0) and post rehabilitation (T7). The ACR (pre/post test) to iso-distance exercise (based on initial ISWT distance) was determined throughout the rehabilitation period at 2 (T2), 4 (T4) weeks and at the end (T7).
Results: 12 patients completed the study. Maximal ISWT distance significantly increased after rehabilitation. There was no significant change in baseline cytokine level throughout; or in pre/post-exercise cytokine levels prior to, during or following rehabilitation.
Conclusions: There was no significant inflammatory response associated with maximal exercise before or after training. Cytokine responses to a fixed bout of exercise did not alter markedly throughout. Clinical PR is unlikely to exacerbate systemic inflammation in COPD.
Keywords: chronic obstructive pulmonary disease, cytokines, exercise