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Matrix metalloproteinases in the wound microenvironment: therapeutic perspectives

Authors Krejner A, Litwiniuk M, Grzela T

Received 12 September 2015

Accepted for publication 9 February 2016

Published 29 March 2016 Volume 2016:3 Pages 29—39

DOI https://doi.org/10.2147/CWCMR.S73819

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Anirban Banerjee

Peer reviewer comments 3

Editor who approved publication: Professor Marco Romanelli


Alicja Krejner,1 Malgorzata Litwiniuk,1–3 Tomasz Grzela1

1Laboratory of Cell Molecular Biology, Department of Histology and Embryology, Biostructure Research Center, Medical University of Warsaw, Warsaw, Poland; 2Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland; 3Department of Otolaryngology, Medical University of Warsaw, Warsaw, Poland

Abstract: Matrix metalloproteinases (MMPs) are key effector molecules responsible for extracellular matrix (ECM) turnover. They are involved in tissue remodeling and regeneration. Although the main targets for MMPs are ECM components, they are also able to digest a variety of non-ECM molecules including cytokines, their receptors, or carriers. Therefore, the activity of the MMPs remains under tight control. However, when controlling mechanisms are ineffective, MMPs may become highly dangerous molecules, which have a strong destructive effect on affected tissues. Apart from cancer metastasis, aneurysm formation, or airway remodeling in asthma, MMPs have also been identified as main detrimental factors in delayed healing of chronic wounds. In this short review, we describe main representatives of MMPs family, their role in pathophysiology of chronic wounds, as well as current and possible therapeutic strategies for modulation of MMPs’ activity, which may be useful in management of chronic wounds.

Keywords: chronic wound, MMPs, MMP inhibitors, wound treatment

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