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Matrix metalloproteinases in bone development and pathology: current knowledge and potential clinical utility

Authors Liang HPH, Xu J, Xue M, Jackson CJ

Received 30 May 2016

Accepted for publication 21 July 2016

Published 12 December 2016 Volume 2016:3 Pages 93—102

DOI https://doi.org/10.2147/MNM.S92187

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Yoshifumi Itoh


Hai Po Helena Liang*, Joshua Xu*, Meilang Xue, Christopher J Jackson

Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Sydney Medical School Northern, University of Sydney, St Leonards, NSW, Australia
 
*These authors contributed equally to this work 

Abstract: Matrix metalloproteinases (MMPs) are degrading enzymes that have a pivotal ­function in extracellular matrix remodeling. More than half of the MMP members are expressed by bone and cartilage cells under physiological or pathological conditions such as rheumatoid arthritis, osteoarthritis, and osteoporosis. Through studies on the various bone diseases and on ­genetically modified mouse models in which one or more of the MMPs or their associated proteins and downstream signaling molecules have been targeted, it is becoming increasingly evident that MMPs and other players in their cellular pathway play a pivotal role in bone development and remodeling. This review details the latest findings related to MMPs and bone development and pathology.

Keywords: bone diseases, mouse models, gelatinases, collagenases, vascular endothelial growth factor, activated protein C, bone morphogenetic proteins, transforming growth factor 

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