Back to Journals » Journal of Blood Medicine » Volume 11

Massive Transfusion Protocols for Pediatric Patients: Current Perspectives

Authors Evangelista ME, Gaffley M, Neff LP

Received 19 February 2020

Accepted for publication 24 April 2020

Published 21 May 2020 Volume 2020:11 Pages 163—172


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin H Bluth

Meagan E Evangelista,1 Michaela Gaffley,1 Lucas P Neff2

1General Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Pediatric Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA

Correspondence: Michaela Gaffley Email

Abstract: In adults, the use of balanced resuscitation and study of massive transfusion protocols have led to improved outcomes for patients and continues to be refined. In children, massive transfusion protocols require further development and study to assess efficacy. Standardization is needed as transfusions and activation of protocols still rely on physician discretion in most pediatric settings. Further research is required to define the pediatric trauma population that will benefit, when to activate these protocols and how to use adjuncts such as tranexamic acid or factor VII in resuscitation. In addition, future implementation of technology such as hemoglobin-based oxygen carriers to increase survival should be studied further in this subset of patients.

Keywords: pediatric trauma, pediatric resuscitation, blood transfusions, pediatric massive transfusion, massive transfusion protocols

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]